MyBioSource.com's PIK3R1 antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The PIK3R1 antibody was generated using GRB1, and PIK3R1 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Phosphoinositide 3-kinase (PI3K) catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival (1). PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN (2). PI3Ks are composed of a catalytic subunit (p110) and a regulatory subunit. Various isoforms of the catalytic subunit (p110a, p110b, p110g, and p110d) have been isolated, and the regulatory subunits that associate with p110a, p110b, and p110d are p85a and p85b (3). In contrast, p110g associates with a p101 regulatory subunit that is unrelated to p85. Furthermore, p110g is activated by bg subunits of heterotrimeric G proteins (4)